Sustained post-exercise vasodilation likely increases delivery of insulin to the microvasculature, where it has been shown to enhance capillary recruitment (Coggins et al., 2001; Vincent et al., 2004; Sjøberg et al., 2017) and may increase nutritive blood flow in patients with T2D (Clark, 2008), thus potentially circumventing insulin resistance in this population. This evidence concerns the gene INS and type 2 diabetes mellitus.