In another study, García-Culebras et al. (2019) demonstrated that mice deficient in TLR4 have a greater polarization for the N2 profile, resulting in a smaller infarct volume and neuroprotection, elucidating a role of TLR4 signaling for neutrophil polarization during the cerebral ischemia (García-Culebras et al., 2019). Here, TLR4 is linked to brain ischemia.