CASP3 and colitis: In 2018, Shi et al. found that a TCM clinical prescription, Qingchang Wenzhong granule (QCWZG), exerted anti-apoptotic effects (0.42–2.20 g/kg) in attenuating DSS-induced colitis rats via inhibiting bax and caspase-3 expressions and enhancing bcl-2 expression (Shi et al., 2019).