INS and Insulin resistance: Unfortunately, as the primary objective of the ADNI cohort did not focus on diabetes, we lacked information on glycosylated hemoglobin, insulin levels and treatment compliance, which are important references for judging the disease conditions and treatment regimens of patients with type 2 diabetes, and can also provide extra clues for exploring whether the insulin resistance had improved and whether standardized management could slow subcortical atrophy and pathological deposition or improve cognition.