In separate models using participant baseline amyloid and tau burden to predict longitudinal trajectories of participant- and study partner-rated cognitive decline over only the first year of data collection (the first four remote sessions), the interaction between amyloid burden and time in study partner-rated cognitive decline remained significant (fixed estimate = 7.13, 95% CI [1.33–12.92], t = 2.43, df = 170, adj. This evidence concerns the gene MAPT and Mental deterioration.