Selective targeting of AMPARs in specific neurons within distinct hypothalamic nuclei could be the foundation of novel therapies for disorders as varied as hypertension (Li et al., 2012), feeding disorders (Florent et al., 2020), circadian clock dysregulation (Rijo-Ferreira and Takahashi, 2019) and social disorders (Carlson, 2012; Kim et al., 2019). Here, CLOCK is linked to hypertensive disorder.