In animal models of HD, the most effective approaches include the use of self-inactivating KamiCas9 system for editing the huntingtin gene (Merienne et al., 2017), injection of mHTT transcription-targeting viral vectors (Zeitler et al., 2019) and application of siRNAs, shRNAs, or miRNAs for the reduction of mHTT mRNA and protein level (see Kaemmerer and Grondin, 2019 for review). Here, HTT is linked to Huntington disease.