That PDE10a belongs to the astrocytic interactor proteins of EAAT2 is new information, but it has been reported that loss of PDE10a could be an important early biomarker of human HD (Ahmad et al., 2014; Russell et al., 2014) and has been considered as a potential target for molecular intervention (Beaumont et al., 2016). The gene discussed is SLC1A2; the disease is Huntington disease.