It was already known that the duration of corticostriatal EPSCs increased in HD mice (Dvorzhak et al., 2019) and, respectively, decreased after the exposure to pharmacological blockers of glutamate transport or modulators of NF-κB-dependent transcription (Lee et al., 2008; Ghosh et al., 2016). This evidence concerns the gene NFKB1 and Huntington disease.