AQP4 and Alzheimer disease: It suggests that AQP4 may serve as a significant predictor for the status of certain diseases, including chronic sleep disruption (Zhang et al., 2020), Alzheimer’s disease (AD) (Zeppenfeld et al., 2017), and traumatic brain injury (TBI) (Piantino et al., 2019), whose pathogeneses are all related to the inefficient waste removal process.