NFKB1 and myasthenia gravis: Fiorillo et al. (2020) showed that the miR-21-5p levels were elevated in AChR+ patients with MG. A further study found a strong overall regulatory relationship between FOXO transcription factors and miR-21-5p. In a murine macrophage cell line, LPS was found to induce the expression of miR-21-5p via NF-κB-mediated inflammatory activation, strengthening the putative role of this miRNA in the MG autoimmune response (Fiorillo et al., 2020).