While they were cytotoxic to MCF-7 breast cancer cells and coculture of MN cells and MCF-7 cells, especially the pequi pulp hydrophilic extract at a concentration of 100 mg/mL, which presented the highest immunomodulatory potential for MCF-7 cells and coculture of MN and MCF-7 cells, they induced anion superoxide production and SOD enzyme production in MCF-7 cells, being the main extract with a promising effect to control disorderly tumor growth in vitro. This evidence concerns the gene SOD1 and breast cancer.