In these tumor cells, IRE1α activation triggered XBP1s expression could drive pro-survival pathways, which results in anti-tumor drug resistance, while MKC-3946 treatment could enhance the tumor cell apoptosis induced by agents like bortezomib, 17-AAG and AS2O3 in vitro and in vivo13, 28. The gene discussed is ERN1; the disease is neoplasm.