Some studies, including our previous work, have shown that 5hmC is significantly lost in renal cell carcinoma and that ascorbic acid (vitamin C) treatment restores the 5hmC pattern of renal cell carcinoma by stimulating the activity of the TET2 enzyme, thereby changing the epigenome and transcriptome of renal cancer cells and inhibiting the related malignant phenotype 13, 17, 18. Here, TET2 is linked to renal cell carcinoma.