Recently, a multiplexed immunoassay revealed neuroinflammatory changes along with diabetic symptoms using different models, including APPswe/PS1dE9 (APP/PS1) mice with high-fat diet (HFD), APP/PS1 with db/db mice, and APP/PS1 with STZ, which found that the levels of both chemokines like MIP-1α, MIP-1β, and MCP-1, and proinflammatory cytokines like Il-1α, Il-3, and IFN-γ were upregulated in these AD pathology-associated T2DM models 19. This evidence concerns the gene APP and type 2 diabetes mellitus.