In addition, it has been reported that the Dectin-2/CARD9/NLRP3 inflammasome signaling in Mo-DCs from the heart is required for IL-1β secretion, based on the following evidence: first, mice with knockout of Dectin-2, CARD9, or mutant SYK, as well as mice with knockout of Nlrp3 or Caspase-1, were completely protected from vasculitis 39. This evidence concerns the gene CARD9 and vasculitis.