PIEZO1 and cancer: Beside migratory role of Piezo1 in various cell including stem cells 141, pancreatic satellite cells 143, and cancers 18, recent study reported that, Piezo1-dependent mechanical triggering of macrophages ex vivo, activates a robust and specific expression of pro-inflammatory as well as chemoattractive mediators 75, thus, initiating and promoting macrophage migratory responses to the inflammatory tissues.