PIEZO1 and atherosclerosis: As mechanical cues are among key determinants of cardiovascular homeostasis, sub-physiological and supraphysiologic mechanical stresses are implicated in abnormal proliferation, migration, apoptosis as well as immune/inflammatory processes and atherosclerosis, including other CVDs, and mechanomedicine could provide hopeful outlook for selective tuning of Piezo1 mechanotransduction for mechanostatic restoration and maintenance.