According to the expression level of SOX8 in each pancreatic cancer cell line (Supplementary Fig. 4), we constructed stable SOX8 overexpressing Panc-1 cell line (Panc-1 SOX8) and Sox8 knockdown CFPAC-1 cell line (CFPAC-1 shSOX8) (Fig. 2A). This evidence concerns the gene SOX8 and familial pancreatic carcinoma.