SPARC and neoplasm: IHC staining of primary tumor displayed that although EZH2 expression level was not change while SPARC expression was increased in UNC1999 group and albumin-bound paclitaxel combined with UNC1999 group (Fig. 6F & Fig. 6G), which indicated that inhibition of EZH2 methylation may reinforce the effect of albumin-bound paclitaxel by increase SPARC expression.