Unbiased microarray analyses on CD4 and CD8 T cells isolated from livers, lymph nodes (LN), and spleens of mice harboring aggressive HCCs (genotype NRASG12V/c-Myc) showed a strong upregulation of several ICIs in situ in livers and LN of HCC-bearing animals in comparison to both tumor-free controls (C1 and C2). Here, CD4 is linked to hepatocellular carcinoma.