On multivariate analysis; type of surgery (elective/emergency) (HR 1.69 95% CI 1.23–2.33, p = 0.002), TNM stage (HR 2.42 95% CI 1.90–3.08, p < 0.001), venous invasion (HR 1.51 95% CI 1.12–2.02, p = 0.007), margin involvement (HR 2.26 95% CI 1.43–3.57, p = 0.001), Klintrup-Mäkinen grade (HR 0.47 95% CI 0.32–0.68, p < 0.001), tumour stroma percentage (HR 1.58 95% CI 1.16–2.14, p = 0.005) and punctate IKKα (HR 1.97 95% CI 1.26–3.08, p = 0.006) were independently associated with reduced cancer-specific survival (Supplementary Table 4). Here, CHUK is linked to neoplasm.