CD8A and neoplasm: Despite the fact that the size and shape of cells remain descriptive, our results are in line with previous data34, emphasizing that the microenvironment is the largest discriminating factor between typical NLPHL and THRLBCL, with an activated CD8+ T cell population in THRLBCL closely attached to tumor cells of THRLBCL leading to cellular stress of the tumor cells, which may explain the low tumor cell content as a result of ineffective proliferation.