CCR5 and HIV infectious disease: Importantly, binding of HIV to CD4/CCR5 leads to HIV infection of the cell whereas binding to some lectin receptors results in rapid uptake into neutral pH Virus Containing Compartments (VCCs) which are invaginations of the plasma membrane.29–31 This compartment is phenotypically identical to the VCCs created in infected macrophages, where they are believed to contribute to viral reservoirs in mucosal tissues.32–34 Connections that link the VCC to the cell surface can be very tight and therefore protect the virus from host immunity.35–37