CXCR4 and acute lymphoblastic leukemia: Combination treatment with the Wnt/β-catenin inhibitor CCT251545 or the CXCR4 inhibitor BL-8040 had synergistic effects on apoptosis induction in T-ALL cells when we cultured them either alone (monoculture) or with BM-derived mesenchymal stromal cells (co-culture) to mimic the BM environment (Fig. 6C, D), demonstrating translational potential.