To further confirm the association between BRD4 and these targets, we used CRISPR to knock out BRD4 in SUP-T1 and KOPT-K1 T-ALL cell lines (Supplementary Fig. 1A) and observed low expression of Myc and CD44 as well as that of CDK4 and CDK6 (Fig. 1D). Here, BRD4 is linked to acute lymphoblastic leukemia.