CLU and Alzheimer disease: Two genes reached exome-wide significance in the EMIF cohort only, but not in the mega-analysis: CHI3L and CLU. CHI3L encodes the YKL-40 protein, which is the primary biomarker loading on the non-AD inflammation PC and was recently identified as a cis-pQTL in a common-variant GWAS in an overlapping set of EMIF-AD MBD and ADNI individuals [16].