Also, increased mRNA expression of TXN, SULF2, CASP1, LPL, ENTPD1, SPP1, DTNA, and UBD was associated with poor HCC prognosis, while mRNA expression of ACHY and SLC27A5 was potentially protective for HCC patients44–54. The gene discussed is SULF2; the disease is hepatocellular carcinoma.