Interestingly, one patient with low grade adenoma and one patient with carcinoma had two concurrent APC deleterious mutations (2 insertions (p.G1481fs and p.E1536fs) in the adenoma sample and 1 deletion (p.E1542fs) and 1 nonsense (p.E1379X) type of APC mutation in the carcinoma sample). Here, APC is linked to carcinoma.