The rather higher KRAS mutation frequency than expected might be explained by the fact that the current study investigated KRAS mutations in codons 12, 13, 61 and 146 covering most of all reported mutations for KRAS in CRC, while earlier studies investigated mostly codon 12 and/or 13 of the KRAS gene only17,18. The gene discussed is KRAS; the disease is colorectal carcinoma.