Furthermore, high concentrations of anti-inflammatory cytokines as IL-1 receptor antagonist (IL-1ra) and proinflammatory cytokines as monocyte chemoattractant protein-1 (MCP-1)36 and interleukin-837 have been found in the cerebrospinal fluid of fibromyalgia37 and migraine patients36 when compared to asymptomatic patients, although the role of inflammation in migraine is still uncertain38,39. The gene discussed is CCL2; the disease is migraine disorder.