LRBA and hereditary disease: Another associated rare variant (EAF cases = 0.0027, lead SNP chr4:rs564716204, P = 1.90e−08) was located nearby LRBA. LRBA (LPS responsive beige-like anchor protein) deficiency is an autosomal recessive genetic disorder caused by mutations resulting in reduced expression and function of the cytotoxic T lymphocyte-associated protein 4 (CTLA4)43.