To elucidate the role that NLRP3 inflammasome plays in viral replication in cells infected with SFTSV, PBMCs were pre-treated with glibenclamide, an NLRP3 inhibitor23, at 1 μM for 6 h, followed by infection of SFTSV at 1 MOI. The gene discussed is NLRP3; the disease is infection.