Fumagillin-105 exhibited DC50 of ~0.7 μM for MetAP2 in HEK293 cells with Dmax, 24 hr of ~1–10 μM (Fig. 2l, m) and DC50 of ~500 nM in U87-MG glioblastoma cells (Fig. 2n). The gene discussed is METAP2; the disease is glioblastoma.