PHTPP-based AUTOTAC (PHTPP-1304) induced self-oligomerization of p62 (Fig. 2c) and degradation of ERβ at half-degrading concentration values (DC50) of ~2 nM in HEK293T cells (Fig. 2d, e) and <100 nM in ACHN renal carcinoma and MCF-7 breast cancer cells (Fig. 2f, g). Here, SQSTM1 is linked to breast cancer.