To further determine the cell autonomous effect of HK2 on metastasis, we generated MMTV-PyMT;Hk2f/f;LSL.Luc;MMTV.rtTATet(O)Cre mice in which HK2 could be specifically deleted in the mammary gland immediately after tumor onset by exposing the mice to doxcycyline diet (Fig. 6f), and found a marked reduction in the metastatic lesions in the lungs. Here, HK2 is linked to neoplasm.