At 2 weeks of infection, as noted previously, there was increased CFU in LN (Fig. 7a) and spleen (Fig. 7b) of Mtb-HT1 compared to Mtb-LT1, whereas, in conjunction with inhibiting AM migration, transient IL-1R blockade also decreased Mtb dissemination to LNs and spleen in Mtb-HT1 infected mice (Fig. 7a, b). The gene discussed is IL1R1; the disease is infection.