CHCHD2 and neurodegenerative disease: Western Blot analysis showed that the degradation rate of CHCH2 mutants, T61I and R145Q, was significantly slower than that of the wild-type CHCHD2 (Fig. 6B, C), indicating that neurodegenerative disease-related CHCHD2 mutants are resistant to degradation by Yme1L and OMA1 under mitochondrial stress.