Mutations of CHCHD10 are associated with ALS- and FTD-like symptoms [14–18], Charcot–Marie–Tooth disease type 2 (CMT2) [19, 20], spinal motor neuronopathy [21], motor neuron disease [15], and mitochondrial myopathy [22]. Here, CHCHD10 is linked to amyotrophic lateral sclerosis.