CHCHD2 and glycogen storage disease VI: However, the recent study would debate this view and suggest that neurodegenerative-disease-linked mutation of CHCHD10 or loss of CHCHD2 and CHCHD10 led to cristae abnormalities because of excessive processing of OPA1, while CHCHD2 or CHCHD10 single knockout did not lead to while CHCHD2 or CHCHD10 single knockout did not induce such effect [35, 36].