VEGFA and neoplasm: 786-O cells transfected with scrambled RNA (si-NC), si-circAFAP1-3 (si-circ), si-circAFAP1-3 accompanied with miR-374b-3p inhibitor (si-circ + inhibitor), and si-circAFAP1-3 coupled with VEGFA overexpression vector (si-circ + VEGFA) were subcutaneously injected and the tumor tissues taken out and measured 21 days after injection (Fig. 5A).