In particular, P-tau/T-tau was reduced in individuals with FTLD-TDP, which is in line with previous findings based on clinical, neuropathologic, and genetic evidence.17,18 The FTLD-TDP group was further characterized by increased NFL, which is also in line with previous literature.47 One biomarker-pathology study in AD and FTLD that compared CSF T-tau and NFL in a panel of biomarkers found that NFL improved diagnostic accuracy, further supporting that NFL can provide important information.48 The gene discussed is NEFL; the disease is Alzheimer disease.