CD56dimCD57+ NK cells from SLE patients showed significantly attenuated cytotoxicity compared with that from HCs when co-cultured with the same allogeneic activated CD4+ T cells (14.5 ± 0.75%, n = 3 versus 20.7 ± 2.38%, n = 3, P < 0.05, Fig. 6B). This evidence concerns the gene CD4 and systemic lupus erythematosus.