The discrepancies between CD56dimCD57+ NK cells and CD56dimCD57− NK cells in SLE patients were similar (CD107a: 31.3 ± 5.46% versus 22.5 ± 4.30%, n = 4; perforin: 82.2 ± 15.1% versus 69.1 ± 20.1%, n = 24; granzyme B: 72.5 ± 23.6% versus 65.3 ± 22.6%, n = 9; CD16: 79.3 ± 17.5% versus 75.2 ± 16.8%, n = 17; NKG2D: 92.5 ± 5.90% versus 89.8 ± 8.87%, n = 10; NKG2A: 26.7 ± 17.3% versus 43.2 ± 23.8%, n = 11; IFN-γ: 16.3 ± 10.6% versus 24.1 ± 8.19%, n = 7; IL-10: 8.51 ± 3.64% versus 10.5 ± 3.82%, n = 6, Fig. 5A, B), but to a lesser extent than that in HCs. This evidence concerns the gene PRF1 and systemic lupus erythematosus.