We also observed a significant impairment in CD107a expression by CD56dimCD57+ NK cells from SLE patients relative to that from HCs (31.3 ± 5.46%, n = 4 versus 60.4 ± 18.6%, n = 4, P < 0.05, Fig. 5A, B). Here, LAMP1 is linked to systemic lupus erythematosus.