By performing a MAGMA gene-level association analysis, we observed that 25 genes including CXCR6, CCR1, IFNAR2, IL10RB, and OAS1 were significantly associated with severe COVID-19 (FDR < 0.05, Additional file 2: Table S5 and Additional file 3: Fig. S9). The gene discussed is IL10RB; the disease is COVID-19.