The inflammatory mediator of EN-RAGE encoded by S100A12 was significantly correlated with COVID-19 [21], and S100A8, S100A9, IRF3, IFI6, IFITM1, and IFITM3 have been reported to elicit autoinflammatory and autoimmune conditions in response to SARS-CoV-2 infection [10, 12, 16, 68, 69]. This evidence concerns the gene IRF3 and COVID-19.