The combination of CK7+/CDX-2+ was reported to have a high sensitivity (71.3%) and specificity (82%) in differential diagnosis of PEAC from colorectal adenocarcinoma, [25] while combining cadherin-17 (negative) and SATB homeobox 2 (negative) also showed high sensitivity (77.0%) and specificity (100%) [26]. This evidence concerns the gene CDX2 and colorectal adenocarcinoma.