In fact, we found a dynamic reduction in the increased levels of monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-2 (MIP-2), keratinocyte-derived chemokine (KC) and monokine induced by gamma interferon (MIG) in plasma following repeated stimulation of D1-receptor-expressing neurons in the nucleus accumbens, whereas the increased level of released cortisol in plasma of tumor-bearing mice was not affected by concomitant stimulation of D1-receptor-expressing neurons in the nucleus accumbens (data not shown). Here, CALCA is linked to neoplasm.