While its role has been elucidated in chronic myeloid leukemia (CML) cells (e.g. [63]) and in acute lymphoblastic leukemia [64], to our knowledge no studies addressing the mechanism linking HERG to CLL B lymphocyte proliferation or pharmacological studies targeting HERG in CLL B cells were performed. This evidence concerns the gene KCNH2 and acute lymphoblastic leukemia.