Decreased CD85j expression was detected in MGUS patients to suggest that CD85j loss is an early event in immune escape. Gene expression profiling of CD85j-overexpressing MM cells revealed a set of downregulated genes with crucial functions in MM pathogenesis and that CD85j overexpression increased susceptibility to T cell- and NK cell-mediated killing. Here, LILRB1 is linked to Miyoshi myopathy.