The findings of this study provide evidence for the modulatory function of DA on NLRP3 inflammasome activation, which is known to link major aspects of PD pathology (neuroinflammation involving activated microglia, α-syn pathology, and dopaminergic neurodegeneration), in primary human microglia as well as the THP-1 model. This evidence concerns the gene NLRP3 and Parkinson disease.