SIRT6 can not only upregulate the expression of tumor suppressors phosphatase and tensin (PTEN), and phosphatidylinositol-4,5-biphosphate (PIP2), but also can downregulate AKT1, mTOR, cyclin D1, and c-myc to inhibit the progression of colon cancer [10]. Here, PTEN is linked to colonic neoplasm.