No significant correlations between low expressed SIRT6 and gender (OR = 0.92, 95% CI = 0.63–1.33, P = 0.226), tumor differentiation (OR = 1.35, 95% CI = 0.68–2.67, P = 0.000), T status (OR = 1.24, 95% CI = 0.70–2.18, P = 0.018), lymph node metastasis (OR = 0.86, 95% CI = 0.55–1.36, P = 0.010) and TNM stage (OR = 0.69, 95% CI = 0.35–1.34, P = 0.001) were observed when the P-value was controlled to be < 0.05 (Additional file 1: Fig. S1). Here, SIRT6 is linked to metastatic malignant neoplasm in the lymph nodes.