AKT1 and colonic neoplasm: SIRT6 can not only upregulate the expression of tumor suppressors phosphatase and tensin (PTEN), and phosphatidylinositol-4,5-biphosphate (PIP2), but also can downregulate AKT1, mTOR, cyclin D1, and c-myc to inhibit the progression of colon cancer [10].