Interestingly, Che et al in 2019 investigated that exosomal-miR-143 was able to decrease the levels of proliferating cell nuclear antigen (PCNA), matrix metalloproteinase (MMP)-2 and MMP-9 expression as well as PC3 cell proliferation, migration, invasion and tumor formation, whereas enhanced apoptosis. This evidence concerns the gene PCNA and neoplasm.