The expression difference of CBX3 in some tumors were further evaluated (Fig. 1b), involving SKCM (Skin cutaneous melanoma), GBM, LAML (Acute myeloid leukemia), DLBC (Lymphoid neoplasm diffuse large B-cell lymphoma), LGG (Brain lower grade glioma), PAAD (Pancreatic adenocarcinoma), TGCT (Testicular germ cell tumors), UCS (Uterine carcinosarcoma) and THYM (Thymoma) (P < 0.05). Here, CBX3 is linked to cutaneous melanoma.