STAT3 and cancer: Rg3 and Rg5 have been shown to suppress the growth of cancers by influencing diverse aspects of tumor cell biology including cell cycle and proliferation, angiogenesis, metastasis and stemness of cancer stem cells through regulating signaling pathways such as PI3K/PKB [18, 36], STAT3 [35], MAPK [37], C/EBPβ/NF-κB [15], Wnt [38] and SNAIL [39].