Hence, our current study examined the impact of Caspase-1 variant rs554344 on the pathological processes of brain amyloidosis, tauopathy, and neurodegeneration, using the baseline and follow-up data from AD-related CSF, PET, and MRI measures in a large non-demented population, including normal cognition (NC) and MCI subgroups, from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. Here, CASP1 is linked to early-onset autosomal dominant Alzheimer disease.