Recent data on diabetic patients showed that the use of either a glucagon-like peptide-1 receptor agonist (liraglutide) alone or in combination with a sodium-glucose cotransporter-2 inhibitor (empagliflozin) increased a number of cardiac work indicators in patients after 4 months of treatment and reduced cardiac failure compared to baseline (P = 0.041 and P < 0.001, respectively). Here, GLP1R is linked to heart failure.