IGF1 and osteoporosis: Notably, diabetes is a predisposing factor of osteoporosis, and patients with diabetes were reported to have a higher risk of fracture, in that the level of insulin‐like growth factor 1 (IGF‐1), a marker of bone formation, is lower in patients with insulin‐dependent diabetes than healthy individuals (Leidig‐Bruckner & Ziegler, 2001).