IP was a selective antagonist of GR—Given that GR as a member of nuclear receptor superfamily exhibits high homology with mineralocorticoid receptor (MR) (Weikum et al., 2017) and IP exhibits beneficial effects on postmenopausal osteoporosis (Gao et al., 2018) similar to estrogens that target estrogen receptors (ERs) (Geller et al., 1998), we evaluated the potential effects of IP on MR and ERs (ERα and ERβ). The gene discussed is ESR2; the disease is postmenopausal osteoporosis.