Here, we found that the K620 acetylation‐mediated formation of the LIFR homodimer drives AKT signalling independent of GP130 in PCa cells, although GP130 can act as a coreceptor that can bind interleukin‐11 (IL‐11), leukaemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), and cardiotrophin‐1 (CT‐1).47 Here, OSM is linked to posterior cortical atrophy.