Moreover, some invasive tumour cells in PTEN‐null mice underwent epithelial‐mesenchymal transition (EMT), as indicated by reduced expression of the epithelial marker E‐cadherin and increased expression of the mesenchymal marker vimentin, which revealed that tumour cells bearing LIFR‐KR mutations inherited disadvantageous metastasis traits (Figure S4C). Here, PTEN is linked to neoplasm.