PTEN mutations and excess PI3K/AKT signalling are generally considered to be pathologically related to PCa because approximately 30% of primary PCa and nearly 70% of metastatic PCa are mutated at the genome locus of the PTEN gene, demonstrating that the PTEN and PI3K/AKT signalling pathways play a key role in the progression of PCa.34, 51. The gene discussed is PTEN; the disease is posterior cortical atrophy.