We observed that LIFR promoted AKT signalling in PCa cells but not under the conditions of PDPK1 blockade, PTEN WT expression, or LIFR‐S1044 mutant expression, which indicated that the signal transduction of LIFR in PCa was dependent on PDPK1 recruitment and a lack of functional PTEN (Figure 5H). This evidence concerns the gene PDPK1 and posterior cortical atrophy.