Capthesin S (CTSS) protein is also strongly associated with NSCLC pathology owing to the fact that CTSS can degrade proteoglycan of interstitial matrix such as decorin (Kehlet et al. 2017) and nidogen-1 (Willumsen et al. 2017) to promote the NSCLC migration. The gene discussed is CTSS; the disease is non-small cell lung carcinoma.