Of interest, no Ashkenazi Jewish–specific BRCA2 variation (p.Ser1982fs) was found in this cohort, which suggests that the BRCA variation is associated with race and ethnicity, similar to the findings of another study.22 In the JHH cohort,5BRCA2 and ATM variations were associated with higher pancreatic cancer risk in the US population, whereas BRCA2 and PALB2 variations were significantly associated with pancreatic cancer risk in the Nanjing cohort. Here, PALB2 is linked to familial pancreatic carcinoma.