SPINK1 and chronic pancreatitis: Among patients with non-PDAC diseases in the Nanjing cohort (Table 4, Figure, B, and eTable 7 in the Supplement), 20 of 98 patients with chronic pancreatitis (20.4%) were found to have pathogenic germline variations, including 18 patients (18.4%) with a recurrent variation of SPINK1 c.194 + 2T>C, 1 patient (1.0%) with both SPINK1 c.194 + 2T>C and BRIP1 p.Leu43fs variations, and 1 patient (1.0%) with a PRSS1 p.Arg122His variation.